Standard dosages

≥ 18 years

Weight	ROA	Load	Dosage
	ROA: iv	Load: -	Dosage: 2g 3 dd

Kidney function

≥ 18 years

ROA	GFR	Dosage	Interval	Comments
ROA: iv
	GFR: 30 - 60	Dosage: 75%	Interval: 8 Hours
	GFR: 15 - 30	Dosage: 50%	Interval: 8 Hours
	GFR: <15		Interval: 12 Hours	Comments: 0.75 g elke 12 uur

Notes GFR general:

(verhoogde) kreatinineklaring >120 ml/min: 2 g elke 6 uur.

.

Continue venoveneuze hemodialyse/hemo(dia)filtratie

effluent flow rate <= 2 l/h: normale startdosis, vervolgens 1.5 g elke 12 uur (= 50% van de normale dosering)

effluent flow rate 2.1-3 l/h: 2 g elke 12 uur (= 67% van de normale dosering)

effluent flow rate 3.1-4 l/h: normale startdosis, vervolgens 1.5 g elke 8 uur (= 75% van de normale dosering)

effluent flow rate > 4 l/h: aanpassen van de dosering is niet nodig

Renal function-replacement therapy

Hemo dialysis: normale startdosis, vervolgens 0.75 g elke 12 uur (= 25% van de normale dosering); op dialysedagen één van de doses direct na de dialyse toedienen

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

• https://www.lareb.nl/mvm-kennis

For individual advice, consult an expert on site.

Metadata

Swab vid: M-501644.6
Updated: 06/27/2025 - 14:04
Status: Published

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